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  1. In this case, the rash persistent for 3 months with associated recalcitrant pruritus that ultimately required specialist dermatology input to ensure resolution. gonorrhea treatment doxycycline Factors such as differences in pharmacodynamics time- dependent or concentration- dependent microbial killing and pharmacokinetics of antimicrobial agents, microbiological characteristics of underlying pathogens, methods applied to determine microbial resistance levels, as well as immunological host factors all may influence the final antimicrobial effect of a given dosage 110.

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